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MYP_126388
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Basic Information
C18-c01W2A
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Standard
15 amino acids
C72H113N23O18
Standard
Sequence
GAWYKGRARPVSAVA
Physicochemical Analysis
1588.81 Da
11.00
2.76
2.55
0.1839
-0.18
0.27
0.00
23.69
65.33
0.1333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
668.00
-6.33
25.0
21.0
47.0
113.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075007 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
H1N1(A/PR/8/34):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells
53 μM
IC50
PaperPubMed PMID: 19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0194103 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0241106 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Influenza A virus (Virus entry); B16
53 μM
Plaque assay
PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0276248 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 60.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0366453 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Alkylated(C18)
Bio-Activity Profile
Antiviral Anti-H1N1 Binding inhibition
H1N1 (A/PR/8/34)
53 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 Jul 23;52(14):4247-56. | DOI:10.1021/jm801570y | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/