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MYP_126327
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Basic Information
Entry 17
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
not Standard
8 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GKRKSXAX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0162966 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'X' at position 6 indicates homophenylalanine(hPhe), position 8 indicates D-homophenylalanine(D-Phg). The N-terminal and C-terminal cyclized by a amide bond.
Bio-Activity Profile
Antiviral Anti-DENV Replication inhibition
Dengue virus 2(DENV2)
15.1 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity. | Takagi Y, Matsui K, Nobori H, Maeda H, Sato A, Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K, Numata Y, Yoshida Y. | Bioorg Med Chem Lett. 2017 Aug 1;27(15):3586-3590. | DOI:10.1016/j.bmcl.2017.05.027 | PMID:28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0166784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide with noncanonical residue [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The 'X' at position 6 and 8 indicates homophenylalanine(hPhe). The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 2(DENV2):inhibition of the activity of NS2B-NS3 protease
25.6 μM
IC50
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0184739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide with noncanonical residue [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The 'X' at position 6 and 8 indicates homophenylalanine(hPhe). The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0222564 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
stereochemistry not specified [Other]
No specific N-terminal
No specific C-terminal
The 'X' at position 6 indicates homophenylalanine(hPhe), position 8 indicates homophenylalanine(Phg). The N-terminal and C-terminal cyclized by a amide bond.
Bio-Activity Profile
Antiviral Anti-DENV Replication inhibition
Dengue virus 2(DENV2)
22.2 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity. | Takagi Y, Matsui K, Nobori H, Maeda H, Sato A, Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K, Numata Y, Yoshida Y. | Bioorg Med Chem Lett. 2017 Aug 1;27(15):3586-3590. | DOI:10.1016/j.bmcl.2017.05.027 | PMID:28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0255794 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide with noncanonical residue [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The 'X' at position 6 indicates homophenylalanine(hPhe), position 8 indicates homophenylalanine(Phg). The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
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