Peptide Database

Peptide NameSomatostatin I

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC110H169N31O34S3

DescriptionStandard

        DNTVRSKPLNCMNYFWKSSTAC
    

Molecular Weight2565.90 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0790

GRAVY Index-0.65

Hydrophobic Moment 0.50

Boman Index-0.14

Instability Index64.47

Aliphatic Index 35.45

Aromaticity 0.1364

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1083.31

LogP -13.30

H-bond Donors 40.0

H-bond Acceptors 39.0

Rotatable Bonds 81.0

Heavy Atoms 178.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0022974 VERIFIED: YES

Provenance & Taxonomy

OrganismIctalurus punctatus [Animal]

FamilySomatostatin

Tax ID7998

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide11-22

Bio-Activity Profile

Function

Hormone Inhibitory neuropeptide

RECORD: Rec_0119499 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0188285 VERIFIED: YES

Provenance & Taxonomy

OrganismIctalurus punctatus [Animal]

FamilySomatostatin

Tax ID7998

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour