Peptide Database

Peptide NameCrotamine

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length42 amino acids

Chemical FormulaC214H332N64O54S7

DescriptionStandard

        YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG
    

Molecular Weight4889.78 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)7.87

Net Charge (pH 7.4) 7.46

Charge Density (pH 7.0) 0.1874

GRAVY Index-1.10

Hydrophobic Moment 0.46

Boman Index-0.27

Instability Index82.60

Aliphatic Index 18.57

Aromaticity 0.1190

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1912.88

LogP -18.07

H-bond Donors 73.0

H-bond Acceptors 71.0

Rotatable Bonds 164.0

Heavy Atoms 339.0

Ring Count 12.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417591 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis ATCC 6633

RECORD: Rec_0418015 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

Familycrotamine-myotoxin family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-36; 11-30; 18-37

Bio-Activity Profile

Function

Antimicrobial crotamine-myotoxin family Antibacterial Antifungal Host defense

RECORD: Rec_0422461 VERIFIED: NO

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-36, 11-30, 18-37

Bio-Activity Profile

Function

Toxin

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