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MYP_126271
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Basic Information
Crotamine
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
42 amino acids
C214H332N64O54S7
Standard
Sequence
YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG
Physicochemical Analysis
4889.78 Da
9.51
7.87
7.46
0.1874
-1.10
0.46
-0.27
82.60
18.57
0.1190
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1912.88
-18.07
73.0
71.0
164.0
339.0
12.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0159116 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic Antifungal
PaperPubMed PMID: 19706485 | PubMed PMID: 16185738 | PubMed PMID: 1176086 | PubMed PMID: 9839677 | PubMed PMID: 22142367 | PubMed PMID: 210622 PMID19706485;16185738;1176086;9839677;22142367;210622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19706485/
RECORD: Rec_0183429 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PMID19706485;31141959 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19706485/
RECORD: Rec_0184835 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antifungal
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23022146/ PMID23022146 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23022146/
RECORD: Rec_0292553 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Crotalus durissus terrificus [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
P. falciparum. Crotamine preferentially targets eukaryotic cells over prokaryotic Kv channels. Structure: The initial NMR structure (PDB: 1H5O) determined by Nicastro G et al. (2003 Eur J Biochem 270: 1969) is verified
PaperYount NY, Kupferwasser D, Spisni A, Dutz SM, Ramjan ZH, Sharma S, Waring AJ, Yeaman MR
RECORD: Rec_0308157 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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