Peptide Database

Peptide NameSLAY-screened peptide P4002

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC66H113N19O18

DescriptionStandard

        TFNLLIRRDILS
    

Molecular Weight1460.72 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)0.40

Net Charge (pH 7.4) 0.21

Charge Density (pH 7.0) 0.0333

GRAVY Index0.47

Hydrophobic Moment 0.33

Boman Index0.01

Instability Index83.23

Aliphatic Index 162.50

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 628.07

LogP -4.55

H-bond Donors 23.0

H-bond Acceptors 19.0

Rotatable Bonds 49.0

Heavy Atoms 103.0

Ring Count 1.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0233523 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/