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MYP_125875
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Basic Information
Peptide-43
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXXGXXXGFXXGXXXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Immunomodulatory
Mycobacterium ranae (ATCC 110)
10 μM
MIC
PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0077643 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium ranae
10 μM
MIC
PatentUS 2012/0197004
RECORD: Rec_0123336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, b = Dab , C terminal -CONH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,6,8,12,14,16,17,18,19; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, b = Dab , C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii WRAIR 13
PMID23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23199484/
RECORD: Rec_0161213 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Dpr = diaminopropionic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Immunomodulatory
Mycobacterium ranae (ATCC 110)
100 μM
MIC
PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0167611 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, b = Dab , C terminal -CONH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,6,8,12,14,16,17,18,19; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, b = Dab , C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae BAMC 07-18
PMID23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23199484/
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