Peptide Database

Peptide NameBac5 (1-17)[F2W; P4,9,17R; Y16W]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC111H177N43O18

DescriptionStandard

        RWRRPIRRRPIRPPFWR
    

Molecular Weight2401.87 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.56

Charge Density (pH 7.0) 0.4565

GRAVY Index-1.91

Hydrophobic Moment 0.58

Boman Index-0.83

Instability Index200.84

Aliphatic Index 45.88

Aromaticity 0.1765

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1020.54

LogP -5.93

H-bond Donors 40.0

H-bond Acceptors 26.0

Rotatable Bonds 71.0

Heavy Atoms 172.0

Ring Count 9.0

Amide Bonds 16.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0394434 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal],synthetic construct [Synthetic]

FamilyCathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)

Tax ID9913;32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

C-TermAmidation

Other ModsF2W; P4R; P9R; Y16W; P17R

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetKlebsiella pneumoniae ATCC 700603

Activity4 μM

MethodMIC

RECORD: Rec_0423745 VERIFIED: YES