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MYP_125871
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Basic Information
Bac5 (1-17)[F2W; P4,9,17R; Y16W]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C111H177N43O18
Standard
Sequence
RWRRPIRRRPIRPPFWR
Physicochemical Analysis
2401.87 Da
12.00
7.76
7.56
0.4565
-1.91
0.58
-0.83
200.84
45.88
0.1765
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1020.54
-5.93
40.0
26.0
71.0
172.0
9.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188504 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
1.7 μM
MIC
PMID34966279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966279/
RECORD: Rec_0192372 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Human RBC [HC50= >278 μM]
278 μM
HC50
PMID34966279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966279/
RECORD: Rec_0203421 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal],synthetic construct [Synthetic]
Cathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)
9913;32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
F2W; P4R; P9R; Y16W; P17R
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae ATCC 700603
>64 μM
MBC
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0216781 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli SSI-NN14 ETEC
1 μM
MIC
PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0225080 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
64 μM
MIC
PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
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