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MYP_125871
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Basic Information
Bac5 (1-17)[F2W; P4,9,17R; Y16W]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C111H177N43O18
Standard
Sequence
RWRRPIRRRPIRPPFWR
Physicochemical Analysis
2401.87 Da
12.00
7.76
7.56
0.4565
-1.91
0.58
-0.83
200.84
45.88
0.1765
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1020.54
-5.93
40.0
26.0
71.0
172.0
9.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104614 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal],synthetic construct [Synthetic]
Cathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)
9913;32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
F2W; P4R; P9R; Y16W; P17R
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli EA22 ETEC
1 μM
MIC
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0138514 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal],synthetic construct [Synthetic]
Cathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)
9913;32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
F2W; P4R; P9R; Y16W; P17R
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli C679-12 EAEC:0104
1 μM
MIC
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0162339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli SSI-OO15 EIEC
1 μM
MIC
PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0164062 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MEC-1
4 %
Cytotoxicity
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii. ChemMedChem. 2019 Dec 17;14(24):2025-2033. doi: 10.1002/cmdc.201900465. PMID: 31692278. PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
RECORD: Rec_0164744 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal],synthetic construct [Synthetic]
Cathelicidin, Bac5, Proline-rich antimicrobial peptide (PrAMP)
9913;32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
F2W; P4R; P9R; Y16W; P17R
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
32 μM
MIC
PaperProline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii PMID31692278 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31692278/
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