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MYP_125769
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Basic Information
P7
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
29 amino acids
C162H249N35O48
Standard
Sequence
SALEEQYKTFLDKFLHELEDLLYQLALAL
Physicochemical Analysis
3454.92 Da
4.35
-4.44
-4.71
-0.1532
0.07
0.65
0.15
32.91
131.38
0.1379
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1349.74
-5.63
45.0
45.0
117.0
245.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014465 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0033458 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2 | Vero-E6 cells
10 μM
% inhibition
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. | Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O. | Commun Biol. 2021 Feb 12;4(1):197. | DOI:10.1038/s42003-021-01736-8 | PMID:33580154 PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0170110 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of replication in Calu-3 cells
1 μM
IC50
PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/
RECORD: Rec_0353365 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of replication in Calu-3 cells
1 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperHuman ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. | Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O. | Commun Biol. 2021 Feb 12;4(1):197. | DOI:10.1038/s42003-021-01736-8 | PMID:33580154 PMID33580154 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33580154/