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MYP_125759
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Basic Information
SL174
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral assembly inhibition ▸ Assembly inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Standard
18 amino acids
C92H131N27O22
Standard
Sequence
GWAGWLLSPRGSRPSWGP
Physicochemical Analysis
1967.19 Da
12.00
1.76
1.56
0.0978
-0.62
0.37
0.10
63.51
48.89
0.1667
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.51
-6.53
28.0
24.0
53.0
141.0
9.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025802 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Infection inhibition
Hepatitis C virus(J6/JFH1) | Huh-7.5 cells
20 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide inhibitors of hepatitis C virus core oligomerization and virus production. | Kota S, Coito C, Mousseau G, Lavergne JP, Strosberg AD. | J Gen Virol. 2009 Jun;90(Pt 6):1319-1328. | DOI:10.1099/vir.0.008565-0 | PMID:19264632 PMID19264632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19264632/
RECORD: Rec_0164948 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
hepatitis C virus(J6/JFH1):inhibition of viral infection in Huh-7
PaperPubMed PMID: 19264632 PMID19264632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19264632/
RECORD: Rec_0189048 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Assembly inhibitor
Hepatitis C virus (Assembly)
EMSA
PaperInterfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein. | Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D. | Can J Microbiol. 2012 | PMID:22452666 PMID22452666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22452666/
RECORD: Rec_0232057 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Hepatitis C virus (Oligomerization); Huh7.5
15 %
ELISA
PaperPeptide inhibitors of hepatitis C virus core oligomerization and virus production. | Kota S, Coito C, Mousseau G, Lavergne JP, Strosberg AD. | J Gen Virol. 2009 | PMID:19264632 PMID19264632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19264632/
RECORD: Rec_0259093 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19264632 PMID19264632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19264632/
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