Peptide Database

Peptide NamePleurain-A1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC358H592N94O105S6

DescriptionStandard

        MFTLKKTLLLLFFLGTISISLCKQERDADEDDGRKMTEEEVKRSIITMTKEAKLPQLWKQIACRLYNTC
    

Molecular Weight8085.49 Da

Isoelectric Point (pI)8.52

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.20

Charge Density (pH 7.0) 0.0215

GRAVY Index-0.27

Hydrophobic Moment 0.56

Boman Index-0.08

Instability Index58.33

Aliphatic Index 93.33

Aromaticity 0.0725

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3272.77

LogP -26.52

H-bond Donors 118.0

H-bond Acceptors 113.0

Rotatable Bonds 284.0

Heavy Atoms 563.0

Ring Count 7.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0068599 VERIFIED: NO

Provenance & Taxonomy

OrganismNidirana pleuraden [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0109022 VERIFIED: YES

Provenance & Taxonomy

OrganismNidirana pleuraden [Animal]

FamilyFrog skin active peptide (FSAP); Pleurain subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetH. pylori (Gram-negative)

RECORD: Rec_0239554 VERIFIED: YES

Provenance & Taxonomy

OrganismNidirana pleuraden [Animal]

FamilyFrog skin active peptide (FSAP); Pleurain subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0251680 VERIFIED: YES

Provenance & Taxonomy

OrganismNidirana pleuraden [Animal]

FamilyFrog skin active peptide (FSAP); Pleurain subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0328644 VERIFIED: YES

Provenance & Taxonomy

OrganismNidirana pleuraden [Animal]

FamilyFrog skin active peptide (FSAP); Pleurain subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus (Gram-positive)