Peptide Database

Peptide NameSLAY-screened peptide P4728

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H152N24O34S

DescriptionStandard

        SPCYDWTLSSIIYHTVTNYS
    

Molecular Weight2350.56 Da

Isoelectric Point (pI)5.06

Net Charge (pH 7.0)-1.46

Net Charge (pH 7.4) -1.74

Charge Density (pH 7.0) -0.0732

GRAVY Index-0.12

Hydrophobic Moment 0.33

Boman Index0.20

Instability Index32.30

Aliphatic Index 73.00

Aromaticity 0.2000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 934.59

LogP -9.16

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 67.0

Heavy Atoms 166.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0416636 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetengineered Escherichia coli surface-display library

Activity-1.218 log2 fold-change MLE

MethodSLAY surface-display dropout screen

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/