Peptide Database

Peptide NameAla45 substitution mutant of pAntp (43-58)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC101H162N34O20S

DescriptionStandard

        RQAKIWFQNRRMKWKK
    

Molecular Weight2204.65 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.4223

GRAVY Index-1.90

Hydrophobic Moment 0.34

Boman Index-0.66

Instability Index51.91

Aliphatic Index 30.62

Aromaticity 0.1875

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 950.45

LogP -6.11

H-bond Donors 35.0

H-bond Acceptors 28.0

Rotatable Bonds 78.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385301 VERIFIED: YES

Provenance & Taxonomy

OrganismDrosophila melanogaster [Animal]

FamilyPenetratin

Tax ID7227

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermBiotinylation

C-TermAmidation

Other ModsN-term detail: Labeled with Biotinyl-bAla

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetHaCat/ A549 cells

MethodCellular uptake assay

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