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MYP_125649
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Basic Information
SFTI-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C67H108N18O19S2
Standard
Sequence
GRCTKSIPPICFPD
Physicochemical Analysis
1533.81 Da
8.06
0.74
0.51
0.0531
-0.13
0.50
0.01
52.64
55.71
0.0714
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
580.93
-5.71
21.0
22.0
44.0
106.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008883 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Conjugation with Alexa Flour 488
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID24985034 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24985034/
RECORD: Rec_0038290 VERIFIED: YES
Provenance & Taxonomy
Helianthus annuus [Plant],Helianthus exilis [Plant],Helianthus tuberosus [Plant]
Bowman-Birk inhibitor
4232
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Protease inhibitor Enzymatic-digestion
PMID11493011;16036910 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11493011/
RECORD: Rec_0041627 VERIFIED: YES
Provenance & Taxonomy
Helianthus annuus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-11
Bio-Activity Profile
Other
PaperPDB 4XOJ structural record; X-ray; 0.91 A; chain B; residues 1-13
RECORD: Rec_0042882 VERIFIED: YES
Provenance & Taxonomy
Helianthus annuus [Plant]
SFTI
4232
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Fluorophore labeling
Cyclization
3-11
N-term detail: Lysine rsidue labeled with Alexa-488; backbone cyclization reported in source
Bio-Activity Profile
Cell-penetrating peptide
RAW 264.7; MCF-7
Fluorescence-based uptake assay
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0103312 VERIFIED: NO
Provenance & Taxonomy
Helianthus annuus [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-11
Bio-Activity Profile
Enzyme inhibitory
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