Peptide Database

Peptide NameBlinatumomab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immunosuppressive

Standard StatusStandard

Sequence Length504 amino acids

Chemical FormulaC2367H3585N649O772S19

DescriptionStandard

        DIQLTQSPASLAVSLGQRATISCKASQSVDYDGDSYLNWYQQIPGQPPKLLIYDASNLVSGIPPRFSGSGSGTDFTLNIHPVEKVDAATYHCQQSTEDPWTFGGGTKLEIKGGGGSGGGGSGGGGSQVQLQQSGAELVRPGSSVKISCKASGYAFSSYWMNWVKQRPGQGLEWIGQIWPGDGDTNYNGKFKGKATLTADESSSTAYMQLSSLASEDSAVYFCARRETTTVGRYYYAMDYWGQGTTVTVSSGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLTVSSVEGGSGGSGGSGGSGGVDDIQLTQSPAIMSASPGEKVTMTCRASSSVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPLTFGAGTKLELKHHHHHH
    

Molecular Weight54093.91 Da

Isoelectric Point (pI)7.22

Net Charge (pH 7.0)0.56

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) 0.0011

GRAVY Index-0.54

Hydrophobic Moment 0.62

Boman Index0.02

Instability Index46.23

Aliphatic Index 54.40

Aromaticity 0.1111

Extinction Coeff. Reduced 120670.00

Extinction Coeff. Oxidized 121170.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221021 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBispecific antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immunosuppressive Monoclonal antibody

Half-Life2.11 h, standard deviation 1.42.

PaperPubMed-linked source references: PMID:28273376; PMID:28096698; PMID:27521873; PMID:27011303; PMID:26667979; PMID:26525683; PMID:26448656; PMID:25999456; PMID:25900401 PMID28273376;28096698;27521873;27011303;26667979;26525683;26448656;25999456;25900401 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28273376/ PatentUS7235641

RECORD: Rec_0227237 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyMonoclonal antibody

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory

Half-Life2.11 hours, standard deviation 1.42.