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MYP_125609
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Basic Information
Peptide P (V13K)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C139H230N36O34
Standard
Sequence
KWKSFLKTFKSAKKTVLHTALKAISS
Physicochemical Analysis
2949.53 Da
10.78
6.84
6.58
0.2631
-0.22
0.65
-0.04
6.56
82.69
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1159.04
-9.39
43.0
42.0
103.0
209.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0323941 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PeptideV13K
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
A-375
17.8 μM
IC50
PaperStudies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework PMID21252288 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21252288/
RECORD: Rec_0325139 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Ala at 12; D-Val at 16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
125 μM
MIC
PMID29280948 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29280948/
RECORD: Rec_0326719 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC25923
PMID24127254 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24127254/
RECORD: Rec_0331048 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Ser at 11; D-Lys at 14
Bio-Activity Profile
Hemolytic
human red blood cells
125 μM
MHC
PMID29280948 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29280948/
RECORD: Rec_0331101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Ala at 12; D-Val at 16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
32 μM
MIC
PMID29280948 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29280948/
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