Peptide Database

Peptide NameHexastatin-1

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC89H129N25O27S2

DescriptionStandard

        ATPFIECSGARGTCHYFAN
    

Molecular Weight2045.26 Da

Isoelectric Point (pI)6.77

Net Charge (pH 7.0)-0.14

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0071

GRAVY Index-0.01

Hydrophobic Moment 0.39

Boman Index0.15

Instability Index92.74

Aliphatic Index 36.32

Aromaticity 0.1579

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 830.22

LogP -9.98

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 60.0

Heavy Atoms 143.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426861 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/

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