Peptide Database

Peptide NamePhospholipase A2; membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Bacteriolytic activity ▸ Bacteriolytic enzyme

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length145 amino acids

Chemical FormulaC698H1110N204O201S18

DescriptionStandard

        MKLLLLLLVVMASDLPQAHGHLKQFTEMIKLTTGKNGLTSYGAYGCHCGVGGKGTPKDATDRCCVRHDCCYDRLMKRGCGTKFLNYRFTHKGSSITCSVKQNSCQKQLCECDKAAAYCFAANLKSYSRRYQFYYNGLCRGKTPSC
    

Molecular Weight16152.70 Da

Isoelectric Point (pI)9.29

Net Charge (pH 7.0)13.79

Net Charge (pH 7.4) 13.07

Charge Density (pH 7.0) 0.0951

GRAVY Index-0.34

Hydrophobic Moment 0.59

Boman Index-0.07

Instability Index29.40

Aliphatic Index 61.93

Aromaticity 0.0966

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 14285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6569.06

LogP -73.38

H-bond Donors 247.0

H-bond Acceptors 238.0

Rotatable Bonds 542.0

Heavy Atoms 1121.0

Ring Count 22.0

Amide Bonds 155.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0350316 VERIFIED: YES

Provenance & Taxonomy

OrganismCavia porcellus [Animal]

FamilyPhospholipase A2

Tax ID10141

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriolytic enzyme Anti-Gram-positive Hydrolase Non-hemolytic

TargetGram Positive Bacteria