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MYP_125527
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Basic Information
GF-17
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C97H164N30O22
Standard
Sequence
GFKRIVQRIKDFLRNLV
Physicochemical Analysis
2102.53 Da
11.72
3.76
3.55
0.2211
-0.09
0.97
-0.19
23.91
125.88
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
890.14
-5.57
32.0
26.0
74.0
149.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0318781 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus UAMS1
3.1 μM
MIC
PMID31319057 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31319057/
RECORD: Rec_0330758 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
E. faecium V284-17
2 μM
MIC
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
RECORD: Rec_0348496 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-EBOV Entry inhibition
Ebola Virus (EBOV) | Hela cells
10.1 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperEngineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K. | iScience. 2020 Apr 24;23(4):100999. | DOI:10.1016/j.isci.2020.100999 | PMID:32252021 PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0348680 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Derivative of [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
FK-16 (residues 17-32 of LL-37) was identified as the major antimicrobial peptide of human cathelicidin LL-37 by NMR-trim. GF-17 = G + FK-16: mol wt 2102.5. Chemical modification: Both GF-17 and FK-16 are C-terminally amidated. SAR: FK-16 and GF-17 have similar antibacterial activity, indicating the N-terminal glycine has a minimal effect (Wang et al., 2019); 17BIPHE2 was designed based on the 3D structure of GF-17d3, which contains three D-amino acids at positions 20, 24, and 28 (numbered as in LL-37) (Wang et al., 2014). 17BIPHE2 is active against the ESKAPE pathogens (MIC 3.1-6.2 uM). Both GF-17 and 17BIPHE2 inhibited Zika virus (He et al., 2018). Updated 4/2013; 10/2013; Jan2014; 4/2016; 4/2017;3/2018; 6/2019; 8/2021; 11/2023; 8/2024; ref link updare 10/2024
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Spermicidal
the ESKAPE pathogens
3.1-6.2 μM
MIC
PaperSolution structures of Human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
RECORD: Rec_0351400 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA300
2-4 μM
MIC
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
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