Peptide Database

Peptide NameKlotho-derived peptide 1

Function Ontology

Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC149H203N39O43

DescriptionStandard

        FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG
    

Molecular Weight3228.44 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0384

GRAVY Index-0.53

Hydrophobic Moment 0.28

Boman Index0.19

Instability Index26.86

Aliphatic Index 32.67

Aromaticity 0.2000

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1312.59

LogP -13.48

H-bond Donors 44.0

H-bond Acceptors 43.0

Rotatable Bonds 99.0

Heavy Atoms 231.0

Ring Count 10.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425237 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyKlotho-derived peptide

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antioxidant Nephroprotective

TargetHuman proximal tubular cells (HKC-8) (In vitro)

MethodWestern blot; Immunostaining; qRT-PCR

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