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MYP_125516
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Basic Information
Klotho-derived peptide 1
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
30 amino acids
C149H203N39O43
Standard
Sequence
FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG
Physicochemical Analysis
3228.44 Da
5.32
-1.15
-1.41
-0.0384
-0.53
0.28
0.19
26.86
32.67
0.2000
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1312.59
-13.48
44.0
43.0
99.0
231.0
10.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119407 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Klotho-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nephroprotective
Rat primary cardiomyocytes (In vivo)
Western blot; Immunostaining; qRT-PCR
PaperA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling PMID35064106 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35064106/
RECORD: Rec_0139414 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Klotho-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nephroprotective
Rat primary cardiac fibroblasts (In vitro)
Western blot; Immunostaining; qRT-PCR
PaperA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling PMID35064106 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35064106/
RECORD: Rec_0239580 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Klotho-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nephroprotective
Normal rat kidney interstitial fibroblast (NRK-49F) (In vitro)
Western blot; Immunostaining; qRT-PCR
PaperA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling PMID35064106 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35064106/
RECORD: Rec_0239599 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Klotho-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nephroprotective
Primary kidney tubular epithelial cells (In vitro)
Western blot; Immunostaining; qRT-PCR
PaperA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling PMID35064106 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35064106/
RECORD: Rec_0422583 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Klotho-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nephroprotective
BALB/c mice (In vivo)
Western blot; Immunostaining; qRT-PCR
PaperA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling PMID35064106 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35064106/
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