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MYP_125471
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Basic Information
Lutetium Lu-177 dotatate
Anticancer
Delivery / Targeting ▸ Targeting ligand ▸ Targeting
Standard
8 amino acids
C49H66N10O12S2
Standard
Sequence
FCYWKTCT
Physicochemical Analysis
1051.24 Da
8.05
0.74
0.50
0.0923
0.04
0.22
0.15
36.54
0.00
0.3750
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
369.52
-1.54
16.0
15.0
29.0
73.0
4.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050274 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Somatostatin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
DOTA
2月7日
DOTA
Bio-Activity Profile
Somatostatin receptor agonist
Somatostatin receptors
Clinical/Human: 71 (± 28) h
Evidence URLhttps://www.ema.europa.eu/en/documents/assessment-report/lutathera-epar-public-assessment-report_en.pdf
RECORD: Rec_0339734 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; synthetic construct [Synthetic]
Somatostatin
9606;32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
DOTA
2月7日
DOTA
Bio-Activity Profile
Diagnostic imaging Somatostatin receptor imaging
Somatostatin receptor-positive neuroendocrine lesions
Clinical/Human: 68 min
Evidence URLhttps://www.fda.gov/news-events/press-announcements/fda-approves-new-diagnostic-imaging-agent-detect-rare-neuroendocrine-tumors
RECORD: Rec_0364859 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; synthetic construct [Synthetic]
Somatostatin
9606;32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
DOTA
DOTA
Bio-Activity Profile
Diagnostic imaging Somatostatin receptor imaging
Somatostatin receptor-positive neuroendocrine lesions
Clinical/Human: 12.7 h
Evidence URLhttps://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-detectnet
RECORD: Rec_0367210 VERIFIED: YES
Provenance & Taxonomy
Bombina bombina [Animal]
Bombesin
8344
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 4-Azido-2,3,5,6-tetrafluorobenzoic acid
Bio-Activity Profile
Anticancer Targeting
PaperTargeted Type 1 phototherapeutic agents using azido-peptide bioconjugates. International Society for Optical Engineering. 2001 Evidence URLhttps://doi.org/10.1117/12.432494
RECORD: Rec_0419904 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amine; Conjugated small molecule: DOTA tri(tert-butyl) ester
Bio-Activity Profile
-
HeLa
PaperDOTA-tris(OPp ester) as a bifunctional prochelator for the preparation of DOTA-peptide conjugates Evidence URLhttps://doi.org/10.1016/j.tetlet.2012.10.007