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MYP_125365
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Basic Information
Diketopiperazine (preWW)
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XW
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005984 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780
89.7 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0059332 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: K562
29.8 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0091375 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Immunomodulatory dipeptide
32630
Structure & Mods
synthetic linear peptide [Linear]
D-glutamyl-L-tryptophan dipeptide [Mixed]
Gamma-D-glutamyl linkage (SCV-07/golotimod)
Bio-Activity Profile
Antiviral Anti-HCV Immunomodulatory
Patients with chronic hepatitis C virus infection
Phase II clinical trial; plasma HCV RNA viral-load assessment
PMID34258744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34258744/
RECORD: Rec_0104828 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Anticancer Cytotoxic
A2780; A2780-cisR; K562
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0264474 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780-cisR
80.8 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
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