Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length44 amino acids

Chemical FormulaC208H312N50O70S5

DescriptionStandard

        MEKAFDLDLEVVHTKAKDVEPDFTSVSFCTPGCGETGSFNSFCC
    

Molecular Weight4793.32 Da

Isoelectric Point (pI)4.28

Net Charge (pH 7.0)-5.44

Net Charge (pH 7.4) -5.78

Charge Density (pH 7.0) -0.1236

GRAVY Index-0.07

Hydrophobic Moment 0.44

Boman Index0.09

Instability Index15.58

Aliphatic Index 48.64

Aromaticity 0.1136

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1907.11

LogP -21.33

H-bond Donors 68.0

H-bond Acceptors 71.0

Rotatable Bonds 154.0

Heavy Atoms 333.0

Ring Count 8.0

Amide Bonds 44.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0139591 VERIFIED: NO

Provenance & Taxonomy

OrganismAlkalihalobacillus clausii [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence