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MYP_125271
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Basic Information
P6(ACE2 (4-26)-G-ACE2 (333-339))
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
31 amino acids
C161H236N42O53
Standard
Sequence
EEQAKTFLDKFNHEAEDLFYQSSGLGKGDFR
Physicochemical Analysis
3607.85 Da
4.70
-3.07
-3.30
-0.0990
-1.06
0.54
-0.16
56.86
44.19
0.1613
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1576.25
-15.80
53.0
51.0
124.0
256.0
6.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0047571 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0268262 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV | HeLa cells
0.1 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0295309 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of pseudovirus infection in HeLa cells
0.1 μM
IC50
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0299901 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Vesicular Stomatitis Virus (VSV) PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
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