Peptide Database

Peptide NameSLAY-screened peptide P4312

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC60H92N16O17S

DescriptionStandard

        TSCPFNLVHGLGP
    

Molecular Weight1341.53 Da

Isoelectric Point (pI)6.40

Net Charge (pH 7.0)-0.52

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0403

GRAVY Index0.38

Hydrophobic Moment 0.30

Boman Index0.34

Instability Index55.96

Aliphatic Index 82.31

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 507.17

LogP -5.37

H-bond Donors 17.0

H-bond Acceptors 19.0

Rotatable Bonds 37.0

Heavy Atoms 94.0

Ring Count 4.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0320047 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/