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MYP_125137
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Basic Information
Cyclopsychotride-A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Neurotensin-inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H229N35O42S6
Standard
Sequence
SIPCGESCVFIPCTVTALLGCSCKSKVCYKN
Physicochemical Analysis
3254.90 Da
8.28
1.40
1.10
0.0451
0.65
0.25
0.20
30.37
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.80
-13.98
48.0
50.0
103.0
222.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0295040 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor
Proteus vulgaris
500 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0296343 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor Anti-Gram-negative
Pseudomonas aeruginosa
50.2 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0296635 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
It is cyclic and contains three disulfide bonds:4,21; 8,23; 13,28
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
>500 μM
MIC
PaperCyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes.
RECORD: Rec_0301334 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21, 8-23, 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
NOTE: Medium with 10 mM phosphate buffer
PMID10430870;7714530 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0314270 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor
Candida tropicalis
500 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
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