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MYP_125137
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Basic Information
Cyclopsychotride-A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Neurotensin-inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H229N35O42S6
Standard
Sequence
SIPCGESCVFIPCTVTALLGCSCKSKVCYKN
Physicochemical Analysis
3254.90 Da
8.28
1.40
1.10
0.0451
0.65
0.25
0.20
30.37
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.80
-13.98
48.0
50.0
103.0
222.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134790 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 29.0%, E 25.8%, T 19.4%, C 25.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0148438 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [other]
Cyclotide
Structure & Mods
cyclic cystine-knot peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Gram-negative and Gram-positive bacteria
PMID7714530;10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7714530/
RECORD: Rec_0149283 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor
Candida kefyr
14 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0154993 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21, 8-23, 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida tropicalis
56.5 μM
MIC
PMID10430870;7714530 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0155933 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
It is cyclic and contains three disulfide bonds:4,21; 8,23; 13,28
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
13.5 μM
MIC
PaperCyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes.
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