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MYP_125137
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Basic Information
Cyclopsychotride-A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Neurotensin-inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H229N35O42S6
Standard
Sequence
SIPCGESCVFIPCTVTALLGCSCKSKVCYKN
Physicochemical Analysis
3254.90 Da
8.28
1.40
1.10
0.0451
0.65
0.25
0.20
30.37
81.61
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.80
-13.98
48.0
50.0
103.0
222.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0036355 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21, 8-23, 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic
PMID10430870;7714530 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0041499 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor Anti-Gram-negative
Escherichia coli
500 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0054320 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor Anti-Gram-positive
Micrococcus luteus
48 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0054879 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21, 8-23, 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
1.55 μM
MIC
PMID10430870;7714530 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0065419 VERIFIED: YES
Provenance & Taxonomy
Psychotria longipes [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Neurotensin-inhibitor Anti-Gram-positive
Staphylococcus aureus
39 μM
MIC
PaperPubMed PMID 10430870 PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
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