Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length631 amino acids

Chemical FormulaC3127H4876N852O876S25

DescriptionStandard

        MKFLGGGIWMRAQRGVWGCLGNDAQSQKSHPITHAHHTYPTHITHTPPTPPPPSPYISHTQHHHTHCYTHTPYMPAKHAPPPHTHTQTCVHTHMSHAHLLPLTPQLPGSTLGPNHGRQQPSPSPAPTQFPSSFLHPTGLHFPSQLLYRSLAPLQGLKALAALEDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESAIRKTMNNKICQVVSSSVSSRLQSYLKTLPVTYKIDRIAGISYSLVAPPTATADNLDGHLKGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLSTNLSMEVSARPDRLVGQLSLDKLLLELKHSDVGSFSVAVLQSIMNYVVPTAVLPKVNERLQEGFPLPMPKNVQLFNLVLQTHQDFLLFGADVHYSG
    

Molecular Weight69222.97 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)15.59

Net Charge (pH 7.4) 13.34

Charge Density (pH 7.0) 0.0247

GRAVY Index-0.10

Hydrophobic Moment 0.75

Boman Index0.12

Instability Index43.62

Aliphatic Index 87.94

Aromaticity 0.0792

Extinction Coeff. Reduced 58330.00

Extinction Coeff. Oxidized 58705.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0075815 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria