Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2227H3594N580O626S20

DescriptionStandard

        MLPLCCILALLASFCHDTSGTTAGVKVKLTQRGLEYGQKIGIPILLKKLKAIDLPEMNDSVGVFLIGRVAYSLTRMKVLNVRLPQSAVGLVPGIGVSLTISDGYIDTGGNWRVKFLGFISDSGTFDLSVCGLTITTTITIKSDGTGRPMVRSANCEASLSHARIRLRGGASWLYNMFNGYINKEVRKELQRKICPLVSENIQKINSYMKTLNVLKKIDRYAEIEYGLTESPVVSVSSTELSLKGEFYNIGVHKKPAFAPTPFSLPPNERNMLYMGISAFTANSAGFVYKNAGALTLRITDDMIPRASPYRLNTKTFEALIPQIAKQYPNMMIKLLVKAATAPTVTFAPNNVTLQANTTVTVYAIQPNTTLTTLFILNDASLSAHVYVIGKNLAGKLIILQRGFPLPNIANISLVKPGLVIMKVSLYPSYEQTWMHEVLNVLCIYEPLL
    

Molecular Weight49151.17 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)17.88

Net Charge (pH 7.4) 17.20

Charge Density (pH 7.0) 0.0399

GRAVY Index0.19

Hydrophobic Moment 0.80

Boman Index0.15

Instability Index33.62

Aliphatic Index 106.63

Aromaticity 0.0804

Extinction Coeff. Reduced 43320.00

Extinction Coeff. Oxidized 43695.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0170183 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence