Peptide Database

Peptide NameSLAY-screened peptide P4661

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC71H108N18O18S2

DescriptionStandard

        NRPTTALMCPYWI
    

Molecular Weight1565.86 Da

Isoelectric Point (pI)8.22

Net Charge (pH 7.0)0.75

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0576

GRAVY Index-0.02

Hydrophobic Moment 0.31

Boman Index0.15

Instability Index30.88

Aliphatic Index 67.69

Aromaticity 0.1538

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 576.41

LogP -3.40

H-bond Donors 21.0

H-bond Acceptors 21.0

Rotatable Bonds 43.0

Heavy Atoms 109.0

Ring Count 5.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0107675 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/