MYP_124898
Gramicidin D
Antimicrobial
Antimicrobial
▸
Antibiotic activity
Antiparasitic
▸
Antimalarial
Antiparasitic
▸
General antiparasitic
▸
Antiparasitic
not Standard
15 amino acids
-
contains X representing unresolved or non-standard residue
VGALAVVVWLXLWLW
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0067363
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
NHCH2CH2OH
Formylation
Xcan be a W(80 to 85%), F(6 to 7%), or Y (5 to 14%). An Ile can also replace the initial Val. This mixture is usually termed gramicidin D
Bio-Activity Profile
Antimicrobial
Antibiotic
Antiparasitic
Antimalarial
Plasmodium vinckei petteri
1.4 mg/kg
ED50; 4 day suppressive test
RECORD: Rec_0089595
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Hydroxyethyl amide
Formylation
Xcan be a W(80 to 85%), F(6 to 7%), or Y (5 to 14%). An Ile can also replace the initial Val. This mixture is usually termed gramicidin D
Bio-Activity Profile
Antimicrobial
Antibiotic
Antiparasitic
Antimalarial
Plasmodium falciparum
3.5e-05 μg/mL
IC50; [3H] Hypoxanthine incorporation assay