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MYP_124888
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Basic Information
E6ap18
Antimicrobial
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
18 amino acids
C89H151N25O33
Standard
Sequence
IPESSELTLQELLGEERR
Physicochemical Analysis
2099.30 Da
4.33
-3.23
-3.44
-0.1792
-0.81
0.46
-0.21
124.16
108.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
963.31
-9.51
33.0
30.0
73.0
147.0
1.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027538 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human papillomavirus(HPV):inhibition of E6-E6ap interaction
10.5±1.4 μM
IC50
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0044367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HPV Entry inhibition
Human papillomavirus(HPV)
10.5±1.4 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 Jun 15;43(23):7421-31. | DOI:10.1021/bi049552a | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0197155 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0311910 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 61.1%, E 0.0%, T 27.8%, C 11.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0338099 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Host-derived peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (E6 protein)
10.5 μM
CD spectroscopy
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/