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MYP_124800
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Basic Information
Mucroporin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C85H138N18O20
Standard
Sequence
LFGLIPSLIGGLVSAFK
Physicochemical Analysis
1732.11 Da
8.75
0.76
0.55
0.0447
1.62
0.42
0.63
17.46
160.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
586.61
-1.89
20.0
21.0
55.0
123.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0233425 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus AB94004
25
MIC
PaperMucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus.
RECORD: Rec_0260271 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus AB94004
25 μg/mL
MIC
PMID20663230;18779362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20663230/
RECORD: Rec_0301278 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0306459 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli AB94012
100 μg/mL
MIC
PMID20663230;18779362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20663230/
RECORD: Rec_0307341 VERIFIED: YES
Provenance & Taxonomy
Lychas mucronatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Methicillin-resistant coagulase-negative S
PMID20663230;18779362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20663230/
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