Peptide Database

Peptide NameSLAY-screened peptide P4737

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC106H168N28O29S

DescriptionStandard

        ASVRPFTCYDPAPLPTLLVRN
    

Molecular Weight2330.70 Da

Isoelectric Point (pI)8.27

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0374

GRAVY Index0.13

Hydrophobic Moment 0.36

Boman Index0.08

Instability Index72.53

Aliphatic Index 92.86

Aromaticity 0.0952

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 895.27

LogP -7.64

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 65.0

Heavy Atoms 164.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019642 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/