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MYP_124669
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Basic Information
Beta-defensin 1TB precursor
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
36 amino acids
C170H266N44O53S6
Standard
Sequence
DHYLCVKNEGICLYSSCPSYTKIEGTCYGGKAKCCK
Physicochemical Analysis
3966.58 Da
8.29
1.79
1.43
0.0496
-0.31
0.30
-0.01
50.97
54.17
0.1111
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1568.87
-16.94
61.0
62.0
130.0
273.0
6.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074654 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 11.1%, E 33.3%, T 33.3%, C 22.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0112352 VERIFIED: YES
Provenance & Taxonomy
Tupaia belangeri [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
12.0 μg/mL
MIC
PMID22939868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22939868/
RECORD: Rec_0126550 VERIFIED: YES
Provenance & Taxonomy
Tupaia belangeri [Animal]
Defensin
37347
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.0 μg/mL
MIC
RECORD: Rec_0143125 VERIFIED: YES
Provenance & Taxonomy
Tupaia belangeri [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0163038 VERIFIED: YES
Provenance & Taxonomy
Mammalia [Animal]
Defensin
40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-27; 12-34; 17-35
Bio-Activity Profile
Antimicrobial
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
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