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MYP_124628
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Basic Information
Alloferon (8-13)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
6 amino acids
C26H39N11O8
Standard
Sequence
QHGVHG
Physicochemical Analysis
633.66 Da
6.92
-0.07
-0.37
-0.0109
-1.08
0.33
0.07
-26.23
48.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
309.27
-4.06
10.0
10.0
19.0
45.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0287874 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Coxsackie virus B2
virus replication inhibition assay
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0288149 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Entry inhibition
Coxsackie virus B2 (clinical strain) | Hep-2 cells
170 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0305168 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Non-cytotoxic
HEp-2 cells
>380 μM
CC50 / cytotoxicity assay
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0346892 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HSV-1
virus replication inhibition assay
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0372747 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Entry inhibition
HHV-1 clinical strain | Vero cells
950 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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