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MYP_124619
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Basic Information
Vpr 65-79
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C83H127N25O20S
Standard
Sequence
QQLLFIHFRIGCQHS
Physicochemical Analysis
1827.12 Da
8.27
0.92
0.61
0.0616
0.14
0.35
0.13
18.46
104.00
0.1333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
739.48
-5.60
26.0
24.0
60.0
129.0
4.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005039 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibit the activity of RNA-dependent DNA polymerase
33 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0005162 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
33 μM
IC50
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0009673 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Inhibition of 3′-end processing catalyzed by integrase
76 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0010859 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibit the activity of Rnase H
16.5 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0030305 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Replication inhibition
HIV
76 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
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