Peptide Database

Peptide NameSLAY-screened peptide P5465

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H166N28O32S

DescriptionStandard

        LPDDFYHNVLICVKRDVNYT
    

Molecular Weight2424.73 Da

Isoelectric Point (pI)5.30

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0581

GRAVY Index-0.20

Hydrophobic Moment 0.50

Boman Index0.01

Instability Index52.75

Aliphatic Index 102.00

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 982.80

LogP -6.80

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 171.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076237 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/