Peptide Database

Peptide NameCryptdin-4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC170H286N62O40S6

DescriptionStandard

        LRGLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR
    

Molecular Weight4030.87 Da

Isoelectric Point (pI)10.13

Net Charge (pH 7.0)8.79

Net Charge (pH 7.4) 8.44

Charge Density (pH 7.0) 0.2584

GRAVY Index-0.46

Hydrophobic Moment 0.68

Boman Index-0.35

Instability Index28.05

Aliphatic Index 65.88

Aromaticity 0.0882

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1688.74

LogP -16.76

H-bond Donors 71.0

H-bond Acceptors 56.0

Rotatable Bonds 135.0

Heavy Atoms 278.0

Ring Count 5.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0316270 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyDefensin

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide6-31; 8-23; 13-30

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

Targetmouse-avirulent Salmonella typhimurium 7953

RECORD: Rec_0376534 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]