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MYP_124545
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Basic Information
Bactofencin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
22 amino acids
C119H190N42O28S4
Standard
Sequence
KRKKHRCRVYNNGMPTGMYRWC
Physicochemical Analysis
2785.31 Da
10.56
6.82
6.53
0.3101
-1.52
0.46
-0.51
59.33
13.18
0.1364
8480.00
8605.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1182.63
-11.47
46.0
40.0
92.0
193.0
6.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0298895 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Cyclic counterpart of Peptide 1: Staphylococcus aureus ATCC 6538
4.3 μM
MIC
PMID30540905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30540905/
RECORD: Rec_0323872 VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22670672 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22670672/
RECORD: Rec_0335580 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus salivarius [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Gram-positive
PaperPubMed PMID: 24169573 PMID24169573 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24169573/
RECORD: Rec_0342982 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus salivarius [Bacterium]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0414434 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-22
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus DPC5246
PaperBactofencin a, a new type of cationic bacteriocin with unusual immunity.
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