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MYP_124515
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Basic Information
Dm-AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C228H337N73O71S9
Standard
Sequence
ELCEKASKTWSGNCGNTGHCDNQCKSWEGAAHGACHVRNGKHMCFCYFNC
Physicochemical Analysis
5525.15 Da
7.80
1.11
0.61
0.0222
-0.69
0.51
-0.08
5.59
21.60
0.1000
12490.00
12990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2330.62
-31.11
88.0
85.0
180.0
381.0
11.0
55.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221755 VERIFIED: YES
Provenance & Taxonomy
Dahlia merckii [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
L. maculans
1.5 μg/mL
IC50
PaperTransgenic expression in Arabidopsis of a polyprotein construct leading to production of two different antimicrobial proteins.
RECORD: Rec_0223959 VERIFIED: YES
Provenance & Taxonomy
Dahlia merckii [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Phosphorylation reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Septoria tritici
1 μg/mL
IC50
PaperPubMed PMID 7628617 | PubMed PMID 1460498 | PubMed PMID 20000000 | Mol Plant Microbe Interact. 2000;13:54-61 | Thevissen K et al 2000 PNAS USA 97: 9531-6 | Montesinos E 2007 FEMS Microbiol Lett 270, 1-11 PMID7628617;1460498;20000000;20000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0225777 VERIFIED: YES
Provenance & Taxonomy
Dahlia merckii [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Fusarium culmorum
8 μg/mL
IC50
PaperPubMed PMID: 13129623 | Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 1995 Jul 17;368(2):257-262. doi: 10.1016/0014-5793(95)00666-W. PMID: 7628617. | PubMed PMID: 8663029 | PubMed PMID: 17216480 PMID13129623;7628617;8663029;17216480 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/13129623/
RECORD: Rec_0226292 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0226855 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US5750504A/en PatentUS 5750504 A
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