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MYP_124471
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Basic Information
Cathelicidin 2 Cl, Cl-CATH2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
34 amino acids
C184H309N69O40
Standard
Sequence
LIQRGRFGRFLGRIRRFRPRINFDIRARGSIRLG
Physicochemical Analysis
4127.86 Da
12.00
9.76
9.56
0.2871
-0.51
0.92
-0.37
24.21
94.71
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1839.44
-17.08
71.0
50.0
142.0
293.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006709 VERIFIED: YES
Provenance & Taxonomy
Columba livia [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 25923
9.38 μg/mL
MIC
PMID26194630 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26194630/
RECORD: Rec_0052933 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0097206 VERIFIED: YES
Provenance & Taxonomy
Columba livia [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (13% Hemolysis at 200 microg/ml
200 μg/mL
Hemolysis
PMID26194630 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26194630/
RECORD: Rec_0114729 VERIFIED: YES
Provenance & Taxonomy
Columba livia [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Stenotrophomonas maltophilia 7407
75 μg/mL
MIC
PMID26194630 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26194630/
RECORD: Rec_0121391 VERIFIED: YES
Provenance & Taxonomy
Columba livia [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella pneumoniae 1400
18.75 μg/mL
MIC
PMID26194630 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26194630/
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