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MYP_124402
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Basic Information
Nocistatin (human)
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
30 amino acids
C149H238N42O53S3
Standard
Sequence
MPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ
Physicochemical Analysis
3561.93 Da
4.26
-5.48
-5.71
-0.1826
-1.42
0.46
-0.29
118.73
39.00
0.0333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1564.75
-15.60
49.0
51.0
124.0
247.0
4.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022062 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Neuromodulator Antinociceptive Analgesic Pain modulation Nociceptin antagonist
nociceptin-induced allodynia and hyperalgesia in a spinal pain model
intrathecal nociception/allodynia-hyperalgesia assay in mice
PaperMinami T, et al. Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br J Pharmacol. 1998;124:1016-1018. DOI:10.1038/sj.bjp.0701995. PMID9720768;25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0024442 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Neuropeptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Neuromodulator Antinociceptive Analgesic Pain modulation Nociceptin antagonist
nociceptin-induced allodynia and hyperalgesia in a spinal pain model
intrathecal nociception/allodynia-hyperalgesia assay in mice
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperMinami T, et al. Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br J Pharmacol. 1998;124:1016-1018. DOI:10.1038/sj.bjp.0701995. PMID9720768 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9168905/
RECORD: Rec_0156134 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Neuropeptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Neuromodulator Antinociceptive Analgesic Pain modulation Nociceptin antagonist
nociceptin-induced allodynia and hyperalgesia in a spinal pain model
intrathecal nociception/allodynia-hyperalgesia assay in mice
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperMinami T, et al. Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br J Pharmacol. 1998;124:1016-1018. DOI:10.1038/sj.bjp.0701995. PMID9720768 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9168905/
RECORD: Rec_0160347 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Opioid
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Neuromodulator Antinociceptive Analgesic Pain modulation Nociceptin antagonist
nociceptin-induced allodynia and hyperalgesia in a spinal pain model
intrathecal nociception/allodynia-hyperalgesia assay in mice
PaperMinami T, et al. Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br J Pharmacol. 1998;124:1016-1018. DOI:10.1038/sj.bjp.0701995. PMID9720768
RECORD: Rec_0357351 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
linear peptide; DSSP H 10.0%, E 0.0%, T 63.3%, C 26.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Neuropeptide Neuromodulator Antinociceptive Analgesic Pain modulation Nociceptin antagonist
nociceptin-induced allodynia and hyperalgesia in a spinal pain model
intrathecal nociception/allodynia-hyperalgesia assay in mice
PaperMinami T, et al. Anti-nociceptive responses produced by human putative counterpart of nocistatin. Br J Pharmacol. 1998;124:1016-1018. DOI:10.1038/sj.bjp.0701995. PMID9720768;21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/