Peptide Database

Peptide NameR-spondin-2

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length222 amino acids

Chemical FormulaC1094H1746N354O316S27

DescriptionStandard

        QGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDRANQ
    

Molecular Weight25779.50 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)24.09

Net Charge (pH 7.4) 23.19

Charge Density (pH 7.0) 0.1085

GRAVY Index-0.92

Hydrophobic Moment 0.64

Boman Index-0.30

Instability Index59.99

Aliphatic Index 41.31

Aromaticity 0.0856

Extinction Coeff. Reduced 29450.00

Extinction Coeff. Oxidized 30825.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0144254 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsAsparagine residue at position 139 is N-linked glycosylated; disulfide bonds between cysteine residues at positions 124 and 166; 135 and 142; 175 and 182

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR4 (Human); LGR5 (Human); LGR6 (Human)

Activity0.0003 nM

MethodEC50