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MYP_124339
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Basic Information
Saposin-like protein SPP-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
89 amino acids
C434H697N117O136S7
Standard
Sequence
GNPANPLNLKKHHGVFCDVCKALVEGGEKVGDDDLDAWLDVNIGTLCWTMLLPLHHECEEELKKVKKELKKDIENKDSPDKACKDVDLC
Physicochemical Analysis
9954.33 Da
5.09
-5.93
-6.46
-0.0666
-0.56
0.67
-0.08
42.86
88.65
0.0337
11000.00
11375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4058.36
-34.98
138.0
141.0
342.0
694.0
13.0
93.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007103 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Saccharomyces cerevisiae S150[LC = 0.5 microM
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0016260 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus megaterium ATCC 14581
0.275 μM
MIC
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0026124 VERIFIED: YES
Provenance & Taxonomy
Caenorhabditis elegans [Animal]
6239
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: Jurkat (Low active up to 10 μM )
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0097117 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Dictyostelium discoideum Ax3-ORF[LC >1 microM
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
RECORD: Rec_0120348 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus megaterium ATCC 14581
0.275 μM
MBC
PMID22519640 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22519640/
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