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MYP_124322
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Basic Information
4306(derived from DNA-polymerase domain of HIV-1 RT (20-mers)),53(derived from the HIV-1 HXB2 Pol region of the viral genome)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
20 amino acids
C103H174N26O31
Standard
Sequence
KQLTEAVQKITTESIVIWGK
Physicochemical Analysis
2272.64 Da
8.50
0.76
0.55
0.0381
-0.12
0.66
0.06
32.29
112.00
0.0500
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
951.77
-7.74
33.0
32.0
79.0
160.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063334 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by soluble mutant integrase
31±7 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/
RECORD: Rec_0151771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Replication inhibition
HIV
7±1 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/
RECORD: Rec_0208718 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. | Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A. | J Biol Chem. 2005 Jun 10;280(23):21987-96. | DOI:10.1074/jbc.M414679200 | PMID:15790559 PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0229416 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by wild-type integrase
51±7 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/
RECORD: Rec_0265085 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by C130S integrase
2±1 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/
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